Chauhan Prem M S, Martins Cristina J A, Horwell David C
School of Chemical Sciences and Pharmacy, University of East Anglia Norwich NR4 7TJ, UK.
Bioorg Med Chem. 2005 May 16;13(10):3513-8. doi: 10.1016/j.bmc.2005.02.055.
Several pteridine analogues 4-13, 23-26 have been synthesized and tested in vitro against three cancer cell lines, MCF7 (breast), NCI-H460 (lung) and SF-268 (CNS). All tested pteridines can serve as novel templates for the anticancer chemotherapy and can serve as new leads in cancer chemotherapy.
已经合成了几种蝶啶类似物4-13、23-26，并在体外针对三种癌细胞系进行了测试，即MCF7（乳腺癌）、NCI-H460（肺癌）和SF-268（中枢神经系统癌）。所有测试的蝶啶都可作为抗癌化疗的新型模板，并可作为癌症化疗的新先导物。
