Oliveira Ana M A G, Oliveira-Campos Ana M F, Rodrigues Lígia M, Raposo M Manuela M, Machado Antonio E H, Nascimento M São José, Nazareth N, Pinto Madalena
Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
Chem Biodivers. 2007 May;4(5):980-90. doi: 10.1002/cbdv.200790089.
The synthesis of five new tetracyclic benzopsoralen analogues, compounds 2-6, with 9H-xanthen-9-one or 9H-carbazole frameworks, is described. Their inhibitory effects on the growth of three human tumor cell lines (MCF-7, SF-268, and NCI-460) were evaluated, and discussed in terms of structure-activity relationship, taking into account both geometric and electronic features. Generally, the angular compounds showed significant biological activities, but the arrangement of functional groups also contributed to the overall activity.
本文描述了五种具有9H-呫吨-9-酮或9H-咔唑骨架的新型四环苯并补骨脂素类似物（化合物2-6）的合成。评估了它们对三种人类肿瘤细胞系（MCF-7、SF-268和NCI-460）生长的抑制作用，并从构效关系方面进行了讨论，同时考虑了几何和电子特征。一般来说，角型化合物显示出显著的生物活性，但官能团的排列也对整体活性有贡献。
