Dworakowska Dorota, Jassem Ewa, Jassem Jacek, Boltze Carsten, Wiedorn Klaus Hermann, Dworakowski Rafał, Skokowski Jan, Jaśkiewicz Kazimierz, Czestochowska Eugenia
Department of Internal Medicine, Endocrinology and Haemostatic Disorders, Medical University of Gdańsk, Poland.
Acta Oncol. 2005;44(1):75-9. doi: 10.1080/02841860510007422.
Prognostic value of p21WAF1/CIP1 expression in non-small-cell lung cancer patients (NSCLC) remains unclear. In this study the authors investigated the clinical significance of p21WAF1/CIP1 expression in a group of 117 NSCLC patients, who underwent curative pulmonary resection. Expression of p21WAF1/CIP1 protein was assessed immunohistochemically and samples showing>5% of positive tumor cells were considered positive. Seventy-six samples (65%) showed positive nuclear p21WAF1/CIP1 protein expression. There was no relationship between the expression of p21WAF1/CIP1 protein and major clinico-pathological factors, and neither there was an impact of p21WAF1/CIP1 protein expression on disease-free and overall survival. p21WAF1/CIP1 protein occurrence was not correlated with previously determined p53 protein expression and there was also no relationship between all possible p21WAF1/CIP1/p53 phenotypes and survival. In uni- and multivariate analysis only stage of disease was independent prognostic factors. These results suggest the lack of prognostic relevance of p21WAF1/CIP1 expression (analyzed separately or jointly with p53 protein) in surgically treated NSCLC patients.
p21WAF1/CIP1表达在非小细胞肺癌（NSCLC）患者中的预后价值仍不清楚。在本研究中，作者调查了117例接受根治性肺切除术的NSCLC患者中p21WAF1/CIP1表达的临床意义。采用免疫组织化学方法评估p21WAF1/CIP1蛋白的表达，肿瘤细胞阳性率>5%的样本被视为阳性。76个样本（65%）显示核p21WAF1/CIP1蛋白表达阳性。p21WAF1/CIP1蛋白表达与主要临床病理因素之间无相关性，p21WAF1/CIP1蛋白表达对无病生存期和总生存期也无影响。p21WAF1/CIP1蛋白的出现与先前测定的p53蛋白表达无关，所有可能的p21WAF1/CIP1/p53表型与生存期之间也无相关性。在单因素和多因素分析中，只有疾病分期是独立的预后因素。这些结果表明，在接受手术治疗的NSCLC患者中，p21WAF1/CIP1表达（单独分析或与p53蛋白联合分析）缺乏预后相关性。
