马拉色菌在特应性皮炎、脂溢性皮炎患者及健康对照者中的患病率。

The prevalence of Malassezia yeasts in patients with atopic dermatitis, seborrhoeic dermatitis and healthy controls.

作者信息

Sandström Falk Mari Helen, Tengvall Linder Maria, Johansson Catharina, Bartosik Jacek, Bäck Ove, Särnhult Tore, Wahlgren Carl-Fredrik, Scheynius Annika, Faergemann Jan

机构信息

Department of Dermatology, Sahlgrenska University Hospital, Gothenburg, Sweden.

出版信息

Acta Derm Venereol. 2005;85(1):17-23. doi: 10.1080/00015550410022276.

DOI:10.1080/00015550410022276

PMID:15848985

Abstract

Cultures for Malassezia yeasts were taken from both normal-looking skin and lesional skin in 124 patients with atopic dermatitis, 16 patients with seborrhoeic dermatitis and from normal skin of 31 healthy controls. Positive Malassezia growth was found in fewer patients with atopic dermatitis (56%) than in patients with seborrhoeic dermatitis (88%) or in healthy controls (84%, p<0.01). In the patients with atopic dermatitis, fewer positive cultures were found in lesional (28%) than in non-lesional skin (44%, p<0.05), while positive cultures were found in 75% of both lesional and non-lesional skin of patients with seborrhoeic dermatitis (not significant). M. sympodialis dominated in patients with atopic dermatitis (46%) and in healthy controls (69%). In patients with seborrhoeic dermatitis both M. sympodialis and M. obtusa were cultured in 43%. A Malassezia species extract mixture would increase the possibility of detecting IgE sensitization to Malassezia in patients with atopic dermatitis.

摘要

从124例特应性皮炎患者外观正常皮肤和皮损处、16例脂溢性皮炎患者以及31名健康对照者的正常皮肤中采集马拉色菌酵母培养物。特应性皮炎患者中马拉色菌生长阳性的比例（56%）低于脂溢性皮炎患者（88%）或健康对照者（84%，p<0.01）。在特应性皮炎患者中，皮损处培养阳性的比例（28%）低于非皮损处皮肤（44%，p<0.05），而脂溢性皮炎患者皮损处和非皮损处皮肤培养阳性率均为75%（无显著差异）。合轴马拉色菌在特应性皮炎患者（46%）和健康对照者（69%）中占主导。在脂溢性皮炎患者中，合轴马拉色菌和钝形马拉色菌培养阳性率均为43%。马拉色菌种提取物混合物会增加检测特应性皮炎患者对马拉色菌IgE致敏的可能性。