Bernier Francois P, Crawford Susan G, Dewey Deborah
Department of Medical Genetics, University of Calgary, Alberta, Canada.
Prenat Diagn. 2005 Apr;25(4):322-6. doi: 10.1002/pd.1135.
The purpose of this study was to evaluate cognitive, motor, language and adaptive behavior development in children who had isolated choroid plexus cysts (CPC) detected prenatally.
A retrospective double cohort design and standardized psychometric measures were used to compare the development of children who had isolated CPCs identified prenatally with a control group of children who had normal prenatal ultrasounds.
Our study cohort (n = 37) had a mean age of 3.88 years (SD = 0.83) and the control cohort (n = 48) had a mean age of 4.62 years (SD = 1.03). The age difference between our cohorts was significant. There were no differences between cohorts in socioeconomic status, sex, birth weight or gestational age. Cognitive data showed no clinically significant difference in Full Scale IQ using the WISC-III or WPPSI-R (CPC = 113.97, control = 116.69). Scores on standardized measures of motor and adaptive functioning also did not show any significant group differences. Children with CPCs did score significantly lower than controls on some of the measures of verbal functioning; however, this difference was not associated with clinically significant delays.
We conclude that the presence of isolated CPCs on midtrimester ultrasound are unlikely to be associated with any significant neurocognitive delays in early childhood.
本研究旨在评估产前检测出孤立性脉络丛囊肿（CPC）的儿童的认知、运动、语言和适应性行为发育情况。
采用回顾性双队列设计和标准化心理测量方法，比较产前确诊为孤立性CPC的儿童与产前超声检查正常的对照组儿童的发育情况。
我们的研究队列（n = 37）平均年龄为3.88岁（标准差 = 0.83），对照队列（n = 48）平均年龄为4.62岁（标准差 = 1.03）。两个队列之间的年龄差异显著。队列之间在社会经济地位、性别、出生体重或孕周方面没有差异。认知数据显示，使用韦氏儿童智力量表第三版（WISC-III）或韦氏学前及初小儿童智力量表修订版（WPPSI-R）测得的全量表智商在临床上没有显著差异（CPC组 = 113.97，对照组 = 116.69）。运动和适应性功能标准化测量的得分也未显示出任何显著的组间差异。患有CPC的儿童在一些语言功能测量上的得分确实显著低于对照组；然而，这种差异与临床上显著的发育延迟无关。
我们得出结论，孕中期超声检查发现孤立性CPC不太可能与幼儿期任何显著的神经认知延迟相关。
