Department of Population and Family Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Prenat Diagn. 2011 Aug;31(8):745-9. doi: 10.1002/pd.2757. Epub 2011 Apr 11.
To examine the effect of isolated prenatal choroid plexus cysts (CPCs) on child cognitive, behavioral, motor, and autonomic development at 18 months of age.
A prospective design was implemented to identify CPC cases and controls in mid-pregnancy. Cases (n = 25) and controls (n = 45) participated in a follow-up visit when children were 18 months of age. Child mental and motor development was assessed using standard developmental assessments, socioemotional and behavioral functioning during testing was rated by examiners, and accelerometers provided measures of motor activity and energy expenditure. Cardiac patterns were collected using a three-lead electrocardiogram (ECG) and quantified as indicators of autonomic control of the heart, including vagal tone.
No significant differences were found in any outcome measure between children with prenatal CPC detection and those without.
Findings should provide reassurance to practitioners and parents that isolated CPCs in fetuses with normal karyotypes do not affect child development after birth.
研究孤立性产前脉络丛囊肿（CPC）对 18 个月龄儿童认知、行为、运动和自主神经发育的影响。
采用前瞻性设计，在妊娠中期识别 CPC 病例和对照组。当儿童 18 个月大时，病例组（n=25）和对照组（n=45）参加了随访。采用标准发育评估评估儿童的精神和运动发育，检查者在测试期间对社会情感和行为功能进行评分，加速度计提供运动活动和能量消耗的测量。使用三导联心电图（ECG）收集心脏模式，并将其量化为心脏自主控制的指标，包括迷走神经张力。
在产前 CPC 检出组和未检出组的任何结局指标中均未发现显著差异。
这些发现应该让从业者和家长放心，即具有正常核型的胎儿孤立性 CPC 不会影响出生后的儿童发育。
