Shvalev V N, Guski H, Fernández-Britto J E, Sosunov A A, Pavlovich E R, Zhuchkova N I, Kargina-Terentyeva R A
Department of Human Cardiovascular Pathology, USSR Academy of Medical Sciences, Moscow.
Acta Histochem Suppl. 1992;42:345-52.
Neurohistochemical and electron microscopic investigations of the autonomic nervous system (ANS) of man and animals suggest that its ontogenesis can be divided into the premediatory, mediatory and postmediatory periods of development. The postmediatory period begins heterochronically in various ganglia of the ANS. A normal process of early cardiac desympathization usually occurs at the age of 35 to 60 years. Specific changes of preceding sudden cardiac death are elicited in different parts of the ANS and adrenal glands. This is accompanied by focal myocardial desympathization. Coronary vessels and conducting system which may influence myocardial hypersensitivity zones to catecholamines are involved in the process of destabilization of the cardiac function. Moreover, relationships are demonstrated which exist between the atherosclerotic lesions of the aortic wall and the status of its nerve plexuses.
对人和动物自主神经系统（ANS）的神经组织化学和电子显微镜研究表明，其个体发生可分为发育的前期、中期和后期。后期在自主神经系统的不同神经节中异时开始。早期心脏去交感神经化的正常过程通常发生在35至60岁之间。在自主神经系统和肾上腺的不同部位会引发心源性猝死前的特定变化。这伴随着局灶性心肌去交感神经化。可能影响心肌对儿茶酚胺过敏区的冠状动脉血管和传导系统参与了心功能失稳的过程。此外，还证明了主动脉壁的动脉粥样硬化病变与其神经丛状态之间存在的关系。
