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[心脏性猝死中的神经体液调节机制紊乱]

[Disorders of neurohumoral regulatory mechanisms in sudden cardiac death].

作者信息

Shavalev V N, Vikhert A M

出版信息

Arkh Patol. 1988;50(11):5-14.

PMID:2906799
Abstract

Trophic function of nervous system (NS) can be now defined as NS capacity for regulating metabolism at the level specific for age and performance status. It is also believed that NS can regulate relevant tissue differentiation employing a combined action of the afferent and efferent NS parts and mediators thereof. The conceptions of cardiac and vascular neurotropism have been recently enriched with evidence gained on quantitative histochemistry of adrenergic and cholinergic plexuses. Normal process of early cardiac desympathization occurs as a rule at the age of 35-60. Specific changes in different parts of autonomic nervous system and adrenal glands proceding sudden cardiac death are elicited. These presented with focal myocardial desympathetization, that of coronary vessels and conducting system which may produce zones of hypersensitivity to catecholamines prone to destabilization of cardiac function.

摘要

神经系统(NS)的营养功能目前可定义为NS在特定年龄和功能状态水平上调节新陈代谢的能力。人们还认为,NS可通过传入和传出NS部分及其介质的联合作用来调节相关组织的分化。心脏和血管神经趋向性的概念最近因肾上腺素能和胆碱能神经丛定量组织化学方面的证据而得到充实。早期心脏去交感神经化的正常过程通常发生在35 - 60岁。自主神经系统和肾上腺不同部位在心脏猝死前会出现特定变化。这些变化表现为局灶性心肌去交感神经化、冠状动脉和传导系统的去交感神经化,这可能会产生对儿茶酚胺敏感的区域,容易导致心脏功能不稳定。

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1
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