[Disorders of neurohumoral regulatory mechanisms in sudden cardiac death].

Trophic function of nervous system (NS) can be now defined as NS capacity for regulating metabolism at the level specific for age and performance status. It is also believed that NS can regulate relevant tissue differentiation employing a combined action of the afferent and efferent NS parts and mediators thereof. The conceptions of cardiac and vascular neurotropism have been recently enriched with evidence gained on quantitative histochemistry of adrenergic and cholinergic plexuses. Normal process of early cardiac desympathization occurs as a rule at the age of 35-60. Specific changes in different parts of autonomic nervous system and adrenal glands proceding sudden cardiac death are elicited. These presented with focal myocardial desympathetization, that of coronary vessels and conducting system which may produce zones of hypersensitivity to catecholamines prone to destabilization of cardiac function.