Menotti A, Descovich G C, Lanti M, Seccareccia F, Dormi A
Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore di Sanità, Roma.
Recenti Prog Med. 1992 Mar;83(3):121-6.
The relationship of indicators of obesity, such as the body mass index (BMI) and the skinfold thickness in some areas (SKIN) to all causes mortality have been analyzed in three italian epidemiological studies. They are the Seven Countries Study--italian areas conducted on 2480 men at entry and followed-up for 25 years; the Brisighella study conducted on 1123 men and 1100 women aged 30-69 and followed-up for 15 years; and the NFR study in Rome conducted on 3395 men aged 46-66 and followed-up of 6.5 years. The univariate analysis concerning the BMI for various age groups, the two sexes, and variable periods of follow-up has almost systematically showed a parabolic inverted J shaped relationship with minimal levels of risk for BMI values of 27-29 units. However this was not the case for the women group and for the oldest men where no clear relationship was found. The analysis concerning the SKIN provided similar but less clear-cut results. The multivariate analysis has confirmed the parabolic relationship of BMI to all causes mortality even in the presence of other 4-5 covariates. The left branch of risk is higher than the right one and its slope could be reduced, although not completely, by the exclusion of heavy smokers, of those who died within the first 5 years of follow-up, of those who were carriers of severe diseases at entry examination.(ABSTRACT TRUNCATED AT 250 WORDS)
在三项意大利流行病学研究中，分析了肥胖指标，如体重指数（BMI）和某些部位的皮褶厚度（SKIN）与全因死亡率之间的关系。它们分别是：七国研究——意大利地区研究，对2480名男性进行了入组研究，并随访了25年；布里西盖拉研究，对1123名男性和1100名年龄在30至69岁之间的女性进行了研究，并随访了15年；以及罗马的NFR研究，对3395名年龄在46至66岁之间的男性进行了研究，并随访了6.5年。对不同年龄组、两性以及不同随访期的BMI进行的单变量分析几乎系统地显示出一种抛物线形倒J形关系，BMI值为27 - 29单位时风险水平最低。然而，女性组和年龄最大的男性组并非如此，未发现明显关系。关于SKIN的分析提供了类似但不那么明确的结果。多变量分析证实了即使存在其他4 - 5个协变量，BMI与全因死亡率之间仍存在抛物线关系。风险的左支高于右支，并且通过排除重度吸烟者、随访前5年内死亡的人以及入组检查时患有严重疾病的人，其斜率可以降低，尽管不能完全消除。（摘要截断于250字）
