胰岛素抵抗的增加与端粒损耗加剧有关。
Rise in insulin resistance is associated with escalated telomere attrition.
作者信息
Gardner Jeffrey P, Li Shengxu, Srinivasan Sathanur R, Chen Wei, Kimura Masayuki, Lu Xiaobin, Berenson Gerald S, Aviv Abraham
机构信息
Hypertension Research Center, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA.
出版信息
Circulation. 2005 May 3;111(17):2171-7. doi: 10.1161/01.CIR.0000163550.70487.0B. Epub 2005 Apr 25.
BACKGROUND
Insulin resistance predisposes to cardiovascular disease and shortens human lifespan. We therefore tested the hypothesis that a rise in insulin resistance in concert with gain in body mass is associated with accelerated white blood cell telomere attrition.
METHODS AND RESULTS
We measured white blood cell telomere dynamics and age-related changes in insulin resistance and body mass index in young adults of the Bogalusa Heart Study. Over 10.1 to 12.8 years, the relative changes in telomere length were correlated with the homeostasis model assessment of insulin resistance (r=-0.531, P<0.001) and changes in the body mass index (r=-0.423, P<0.001).
CONCLUSIONS
These findings provide the first tangible nexus of telomere biology with insulin resistance and adiposity in humans.
背景
胰岛素抵抗易引发心血管疾病并缩短人类寿命。因此，我们检验了这样一个假设，即胰岛素抵抗增加与体重增加同时出现会加速白细胞端粒损耗。
方法与结果
我们在博加卢萨心脏研究的年轻成年人中测量了白细胞端粒动态变化以及与年龄相关的胰岛素抵抗和体重指数变化。在10.1至12.8年的时间里，端粒长度的相对变化与胰岛素抵抗的稳态模型评估值（r = -0.531，P < 0.001）以及体重指数的变化（r = -0.423，P < 0.001）相关。
结论
这些发现首次在人类中建立了端粒生物学与胰岛素抵抗及肥胖之间的切实联系。
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