Baliou Stella, Apetroaei Miruna-Maria, Hatzidaki Eleftheria, Kuzmin Sergey V, Tzatzarakis Manolis N, Arsene Andreea Letiția, Tsatsakis Aristides, Ioannou Petros
Laboratory of Toxicology, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 020956 Bucharest, Romania.
Life (Basel). 2025 May 28;15(6):873. doi: 10.3390/life15060873.
The worldwide prevalence of obesity continues to increase, representing a serious public health issue due to associated comorbidities. Obesity is associated with type 2 diabetes mellitus (T2D), which shares similar pathophysiological mechanisms. In both conditions, oxidative stress, inflammation, mitochondrial dysfunction, abnormal adipose tissue function, and senescence are observed, ultimately leading to insulin resistance. In both cases, hypertrophic adipose tissue is associated with telomere shortening. Elucidating the mechanisms underlying telomere shortening in obesity and diabetes may be crucial for deepening our understanding of these pathologies, with the ultimate aim of its translational implications. Several studies have shown that telomere shortening is present in patients with metabolic disorders, emphasizing its prognostic value for the onset and progression of these diseases. From this perspective, this article highlights the importance of telomere biology, which can aid in developing new therapeutic options for metabolic disorders.
全球肥胖患病率持续上升，由于相关合并症，这已成为一个严重的公共卫生问题。肥胖与2型糖尿病（T2D）相关，二者具有相似的病理生理机制。在这两种情况下，均会观察到氧化应激、炎症、线粒体功能障碍、脂肪组织功能异常和衰老，最终导致胰岛素抵抗。在这两种病例中，肥大的脂肪组织都与端粒缩短有关。阐明肥胖和糖尿病中端粒缩短的潜在机制，对于加深我们对这些疾病的理解可能至关重要，其最终目标是实现转化应用。多项研究表明，代谢紊乱患者存在端粒缩短的情况，这凸显了其对这些疾病发生和进展的预后价值。从这个角度来看，本文强调了端粒生物学的重要性，它有助于开发针对代谢紊乱的新治疗方案。
