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体外与体内:壬苯醇醚9的故事

In vitro and in vivo: the story of nonoxynol 9.

作者信息

Hillier Sharon L, Moench Thomas, Shattock Robin, Black Roberta, Reichelderfer Patricia, Veronese Fulvia

机构信息

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

出版信息

J Acquir Immune Defic Syndr. 2005 May 1;39(1):1-8. doi: 10.1097/01.qai.0000159671.25950.74.

Abstract

There is an urgent need to expand the range of interventions to prevent HIV transmission and acquisition, especially those that can be controlled by women. Microbicides, defined as antimicrobial products that can be applied topically for the prevention of HIV and other sexually transmitted infections, may offer one of the most promising preventive interventions, because they could be inexpensive, readily available, and widely acceptable. The first microbial product to be clinically evaluated contained Nonoxynol-9 (nonylpenoxypolyethoxyethanol [N-9]), a nonionic surfactant, as the active agent. This article presents a review of the in vitro, ex vivo, and animal model data on the safety of N-9 and a critical analysis of their predictive power based on the results of multiple safety and efficacy trials.

摘要

迫切需要扩大预防艾滋病毒传播和感染的干预措施范围,尤其是那些可由女性掌控的措施。杀微生物剂被定义为可局部应用以预防艾滋病毒和其他性传播感染的抗菌产品,可能是最具前景的预防干预措施之一,因为它们价格低廉、易于获取且广泛可接受。首个接受临床评估的杀微生物产品含有壬苯醇醚-9(壬基苯氧基聚乙氧基乙醇 [N-9]),一种非离子表面活性剂,作为活性剂。本文综述了关于N-9安全性的体外、离体和动物模型数据,并根据多项安全性和有效性试验结果对其预测能力进行了批判性分析。

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