Cooke J D, Eastman M J
Exp Brain Res. 1977 Apr 21;27(5):491-500. doi: 10.1007/BF00239038.
EMG responses to sudden displacement of the forelimb were studied in Cebus monkeys tranquilized with Atravet, a phenothiazine tranquilizer. The monkey's forearm was strapped firmly to a manipulandum handle. A torque motor attached at the pivot point of the handle, under servo control, provided reproducible limb displacements. In response to a sudden maintained displacement three periods of EMG activation in biceps muscle occurred with peak latencies of approximately 25, 45 and 85 msec. These correspond to the latencies of the M1, M2 and M3 responses in the alert animal. Similar responses were observed in 'naive' animals which had not previously been used in experimentation. All three responses increased in magnitude with increasing background activity and all appeared to be associated with suppression of EMG activity in the antagonist muscle. M1 and M2 responses were position dependent, M1 being greater in extension than in flexion and M2 the opposite. The position-dependence of the M2 response was produced by a depression of activity following the M1. This depression of activity lasted up to 30 msec following M1 and was directly dependent on the M1 magnitude.
在使用非那嗪类镇静剂Atravet进行镇静的僧帽猴身上，研究了肌电图（EMG）对前肢突然移位的反应。猴子的前臂被牢固地绑在一个操作手柄上。一个连接在手柄枢轴点的扭矩电机在伺服控制下，提供可重复的肢体移位。对突然持续的移位做出反应时，肱二头肌出现了三个肌电图激活期，峰值潜伏期约为25、45和85毫秒。这些潜伏期与警觉动物中的M1、M2和M3反应的潜伏期相对应。在以前未用于实验的“未接触过实验的”动物中也观察到了类似的反应。随着背景活动的增加，所有这三种反应的幅度都增大，并且似乎都与拮抗肌中肌电图活动的抑制有关。M1和M2反应与位置有关，M1在伸展时比在屈曲时更大，而M2则相反。M2反应的位置依赖性是由M1之后的活动抑制产生的。这种活动抑制在M1之后持续长达30毫秒，并且直接取决于M1的幅度。
