Denver Dee R, Morris Krystalynne, Streelman J Todd, Kim Stuart K, Lynch Michael, Thomas W Kelley
Department of Biology, Indiana University, Bloomington, Indiana 47405, USA.
Nat Genet. 2005 May;37(5):544-8. doi: 10.1038/ng1554. Epub 2005 Apr 24.
The evolutionary importance of gene-expression divergence is unclear: some studies suggest that it is an important mechanism for evolution by natural selection, whereas others claim that most between-species regulatory changes are neutral or nearly neutral. We examined global transcriptional divergence patterns in a set of Caenorhabditis elegans mutation-accumulation lines and natural isolate lines to provide insights into the evolutionary importance of transcriptional variation and to discriminate between the forces of mutation and natural selection in shaping the evolution of gene expression. We detected the effects of selection on transcriptional divergence patterns and characterized them with respect to coexpressed gene sets, chromosomal clustering of expression changes and functional gene categories. We directly compared observed transcriptional variation patterns in the mutation-accumulation and natural isolate lines to a neutral model of transcriptome evolution to show that strong stabilizing selection dominates the evolution of transcriptional change for thousands of C. elegans expressed sequences.
一些研究表明，它是自然选择驱动进化的重要机制，而另一些研究则认为，大多数物种间的调控变化是中性或近乎中性的。我们研究了一组秀丽隐杆线虫突变积累系和自然分离系中的全局转录差异模式，以深入了解转录变异在进化中的重要性，并区分突变和自然选择在塑造基因表达进化过程中的作用。我们检测了选择对转录差异模式的影响，并根据共表达基因集、表达变化的染色体聚类和功能基因类别对其进行了表征。我们将突变积累系和自然分离系中观察到的转录变异模式与转录组进化的中性模型进行了直接比较，以表明强烈的稳定选择主导了数千个秀丽隐杆线虫表达序列转录变化的进化。
