Hoeg-Jensen Thomas, Havelund Svend, Nielsen Peter K, Markussen Jan
Novo Nordisk, Novo Alle 6B2.54, DK-2880 Bagsvaerd, Denmark.
J Am Chem Soc. 2005 May 4;127(17):6158-9. doi: 10.1021/ja051038k.
Insulin with built-in pairs of boronates and polyols can produce soluble high molecular weight self-assemblies under control by carbohydrates. The illustrated principle has potential utility for general protein and peptide protraction and controlled drug release.
