Deep brain stimulation has become a topic of intense interest both from a clinical and basic science perspective. Its indications, currently including Parkinson's disease, tremor and dystonia, may expand in the future to include not only other movement disorders but also epilepsy, obsessive-compulsive disorder and other neuropsychiatric conditions. The mechanism(s) of action of deep brain stimulation have only recently begun to be characterized and have already yielded surprises that may open the door to a greater expansion of the indications for this novel and powerful therapeutic intervention.