Coffey Robert J
Medtronic, Inc., 7000 Central Avenue NE, Minneapolis, MN 55432, USA.
Artif Organs. 2009 Mar;33(3):208-20. doi: 10.1111/j.1525-1594.2008.00620.x. Epub 2008 Jul 31.
Deep brain stimulation (DBS)--a broadly accepted therapeutic modality with tens of thousands of patients currently implanted--is the application of implantable electrical stimulation devices to treat neurological disorders. Approved indications include involuntary movement disorders; investigational applications include epilepsy, selected psychiatric disorders, and other conditions. DBS differs fundamentally from functional electrical stimulation and sensory prosthetics in that DBS therapies do not substitute for or replace injured tissues, organs, or body functions. DBS--targeted to particular brain nuclei or pathways that are specific for the disorder under treatment--influences brain function and behavioral output in ways that can relieve symptoms and improve the overall functioning of the patient. We will briefly review the history and present status of DBS from a technical and device-oriented perspective, with an eye toward future advances.
深部脑刺激（DBS）——一种被广泛接受的治疗方式，目前已有数万名患者植入了相关设备——是指应用可植入式电刺激装置来治疗神经系统疾病。获批的适应症包括非自主运动障碍；正在研究的应用领域包括癫痫、某些精神疾病及其他病症。DBS与功能性电刺激和感觉假体有着根本区别，因为DBS疗法并不替代受损的组织、器官或身体功能。针对特定脑核团或与所治疗疾病相关的特定神经通路的DBS，以能够缓解症状并改善患者整体功能的方式影响脑功能和行为输出。我们将从技术和设备导向的角度简要回顾DBS的历史和现状，并展望未来的进展。
