Ilbäck N G, Fohlman J, Friman G
Toxicology Laboratory, National Food Administration, Uppsala, Sweden.
Toxicol Appl Pharmacol. 1992 May;114(1):166-70. doi: 10.1016/0041-008x(92)90110-e.
The autoradiographic distribution of the toxic heavy metal nickel (Ni) was studied at 4 and 7 days post-coxsackievirus B3 (CB3) infection in Balb/c mice. The distribution of the iv injected 63Ni was studied 10 min, 4 hr, and 24 hr after administration. Results clearly show that the site of 63Ni accumulation is greatly changed during this viral infection. This newly discovered distribution was mainly visible as a greatly increased accumulation in the pancreas and the wall of the ventricular myocardium. Healthy animals showed almost no 63Ni accumulation in these tissues. These results for the first time show that an invading microorganism can change the distribution of an environmental pollutant.
在柯萨奇病毒B3（CB3）感染Balb/c小鼠后的第4天和第7天，研究了有毒重金属镍（Ni）的放射自显影分布。在静脉注射63Ni后的10分钟、4小时和24小时研究了其分布情况。结果清楚地表明，在这种病毒感染期间，63Ni的积累部位发生了很大变化。这种新发现的分布主要表现为胰腺和心室心肌壁中的积累大幅增加。健康动物在这些组织中几乎没有63Ni积累。这些结果首次表明，入侵的微生物可以改变环境污染物的分布。
