Ilbäck N G, Fohlman J, Friman G, Glynn A W
Toxicology Laboratory, National Food Administration, Uppsala, Sweden.
Toxicology. 1992;71(3):193-202. doi: 10.1016/0300-483x(92)90023-8.
The distribution of the toxic heavy metal cadmium (Cd) was studied in Coxsackie virus B3 (CB3)-infected Balb/c mice by whole-body autoradiography and gamma-counting. The distribution of 109Cd was studied 4 days post CB3-inoculation and 10 min after intravenous injection of 0.21 microgram of Cd/kg body weight. Whole-body autoradiography results showed that the distribution of 109Cd is greatly changed during this viral infection. This newly discovered distribution was mainly visible as a greatly increased accumulation in the renal and adrenal cortices. After impulse counting of selected organs it was found that the normal accumulation of 109Cd in the kidneys (184,354 +/- 30,961 c.p.m.) was increased by 47% (P less than 0.05) during CB3 infection (270,503 +/- 54,780 c.p.m.). In contrast to healthy animals, some infected mice showed accumulation of 109Cd in the spleen. These results show for the first time that an invading micro-organism can change the distribution of an environmental pollutant.
通过全身放射自显影和γ计数法，研究了柯萨奇病毒B3（CB3）感染的Balb/c小鼠体内有毒重金属镉（Cd）的分布情况。在接种CB3后4天，以及静脉注射0.21微克Cd/千克体重10分钟后，对109Cd的分布进行了研究。全身放射自显影结果表明，在这种病毒感染期间，109Cd的分布发生了很大变化。这种新发现的分布主要表现为在肾皮质和肾上腺皮质中的蓄积大幅增加。对选定器官进行脉冲计数后发现，在CB3感染期间（270,503±54,780次/分钟），肾脏中109Cd的正常蓄积量（184,354±30,961次/分钟）增加了47%（P<0.05）。与健康动物不同，一些感染小鼠的脾脏中出现了109Cd的蓄积。这些结果首次表明，入侵的微生物可以改变环境污染物的分布。
