Kim H-N, Vorona R D, Winn M P, Doviak M, Johnson D A, Ware J Catesby
Department of Internal Medicine, University of Virginia, Charlottesville, VA, USA.
Aliment Pharmacol Ther. 2005 May 1;21(9):1127-33. doi: 10.1111/j.1365-2036.2005.02447.x.
Studies suggest obstructive sleep apnea syndrome (OSAS) frequently manifests in patients with gastroesophageal reflux disease (GERD) and that there may be a causal relationship.
To determine the relationship between OSAS and symptoms of GERD.
Consecutive patients referred to the Sleep Disorders Center (SDC) 18 years and older with polysomnographically defined OSAS were evaluated prospectively for GERD using a validated symptoms questionnaire. The GERD and OSAS relationship was assessed by 1) determining frequency of GERD in patients with and without OSAS; 2) ascertaining the relationship between OSAS severity categories and presence of GERD; 3) examining GERD score in relation to those factors that might affect both GERD and OSAS, e.g. obesity.
One thousand and twenty-three SDC patients met entry criteria. Amongst participants, GERD was common (29% of women and 17% of males) and OSAS extremely common (58% of women and 80% of males). GERD score did not correlate with OSAS variables. The severity of OSAS did not influence the prevalence of GERD.
In a large group of patients referred to a sleep disorders center, there was no relationship between OSAS and GERD symptoms. Also, there was no relationship between the severity of OSAS and the likelihood of GERD symptoms.
研究表明,阻塞性睡眠呼吸暂停综合征(OSAS)在胃食管反流病(GERD)患者中经常出现,且可能存在因果关系。
确定OSAS与GERD症状之间的关系。
对18岁及以上因多导睡眠图确诊为OSAS而转诊至睡眠障碍中心(SDC)的连续患者,使用经过验证的症状问卷对GERD进行前瞻性评估。通过以下方式评估GERD与OSAS的关系:1)确定有和无OSAS患者中GERD的发生率;2)确定OSAS严重程度类别与GERD存在之间的关系;3)检查GERD评分与可能影响GERD和OSAS的因素(如肥胖)之间的关系。
1023名SDC患者符合纳入标准。在参与者中,GERD很常见(女性为29%,男性为17%),OSAS极为常见(女性为58%,男性为80%)。GERD评分与OSAS变量无关。OSAS的严重程度不影响GERD的患病率。
在一大组转诊至睡眠障碍中心的患者中,OSAS与GERD症状之间没有关系。此外,OSAS的严重程度与GERD症状的可能性之间也没有关系。