Lindam Anna, Ness-Jensen Eivind, Jansson Catarina, Nordenstedt Helena, Åkerstedt Torbjörn, Hveem Kristian, Lagergren Jesper
Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
Sleep. 2016 Jul 1;39(7):1421-7. doi: 10.5665/sleep.5976.
To investigate the potentially bidirectional association between gastroesophageal reflux symptoms (GERS) and sleep disturbances/ insomnia disorders.
We assessed the incidence of new-onset of self-reported GERS, sleep disturbances, and insomnia disorders in a population-based longitudinal cohort study (HUNT), performed in Nord-Trøndelag County, Norway. Modified Poisson regression was used to estimate risk ratios (RRs) with 95% confidence intervals (CIs), adjusted for sex, age, body mass index, tobacco smoking, educational level, anxiety, and depression.
The study cohort included the 25,844 participants of the HUNT study who responded to health questionnaires in both 1995-1997 and 2006-2009. New-onset GERS, sleep disturbances, and insomnia disorders was reported in 396 (2%), 2,598 (16%), and 497 (3%) participants, respectively. Persistent sleep disturbances were associated with new-onset GERS (RR: 2.70, 95% CI: 1.93-3.76), persistent insomnia disorders were associated with new-onset GERS (RR: 3.42; 95% CI: 1.83-6.39) and persistent GERS was associated with new-onset sleep disturbances (RR: 1.41; 95% CI: 1.14-1.75).
Sleep disturbances and GERS seem to be bidirectionally associated, and sleep disturbances seem to be a stronger risk factor for GERS than the reverse.
探讨胃食管反流症状（GERS）与睡眠障碍/失眠症之间潜在的双向关联。
在挪威北特伦德拉格郡进行的一项基于人群的纵向队列研究（HUNT）中，我们评估了自我报告的新发GERS、睡眠障碍和失眠症的发生率。采用修正泊松回归来估计风险比（RRs）及95%置信区间（CIs），并对性别、年龄、体重指数、吸烟、教育水平、焦虑和抑郁进行了调整。
研究队列包括HUNT研究中在1995 - 1997年和2006 - 2009年都回复了健康问卷的25844名参与者。分别有396名（2%）、2598名（16%）和497名（3%）参与者报告了新发GERS、睡眠障碍和失眠症。持续性睡眠障碍与新发GERS相关（RR：2.70，95% CI：1.93 - 3.76），持续性失眠症与新发GERS相关（RR：3.42；95% CI：1.83 - 6.39），持续性GERS与新发睡眠障碍相关（RR：1.41；95% CI：1.14 - 1.75）。
睡眠障碍和GERS似乎存在双向关联，且睡眠障碍似乎是GERS比其反向关联更强的风险因素。
