从无保护的还原糖一锅法合成全O-乙酰化硫代糖苷。
One-pot synthesis of per-O-acetylated thioglycosides from unprotected reducing sugars.
作者信息
Agnihotri Geetanjali, Tiwari Pallavi, Misra Anup Kumar
机构信息
Medicinal and Process Chemistry Division, Central Drug Research Institute (CDRI), Chattar Manzil Palace, Lucknow 226001, UP, India.
出版信息
Carbohydr Res. 2005 May 23;340(7):1393-6. doi: 10.1016/j.carres.2005.02.027.
PMID:15854611
Abstract
A sequential per-O-acetylation and thioglycosidation of unprotected reducing sugars using a stoichiometric quantity of acetic anhydride and alkyl- or arylthiols is reported. These reactions, which are catalyzed by BF3.OEt2, together constitute an efficient one-pot method for the synthesis of acetylated thioglycosides.
摘要
报道了使用化学计量的乙酸酐和烷基或芳基硫醇对未保护的还原糖进行顺序的全-O-乙酰化和硫代糖苷化反应。这些由BF3.OEt2催化的反应共同构成了一种高效的一锅法合成乙酰化硫代糖苷的方法。
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