Chen Jyun-Siao, Lo Tai-Chung, Hsieh Ya-Chi, Chen Ching-Hsien, Lin Michelle, Lin Heng-Yan, Hung Ming-Wei, Wu Hsin-Ru, Luo Shun-Yuan
Department of Chemistry, National Chung Hsing University, Taichung 40227, Taiwan.
Morrison Academy, Taichung 40679, Taiwan.
ACS Omega. 2023 Feb 21;8(9):8885-8893. doi: 10.1021/acsomega.3c00362. eCollection 2023 Mar 7.
Traditional methods for synthesizing complex oligosaccharides currently developed are not efficient, requiring a new glycosylation methodology. Herein, using phosphotungstic acid (PTA) as a catalyst has demonstrated to be a simple possibility for carbohydrate synthesis. The methodology is engineered into a PTA-catalyzed thioglycoside preparation under microwave conditions and de--acetylation of carbohydrates. These easier operations and convenient protocols display a wide substrate scope. Moreover, both methods can be developed into a one-pot reaction for the efficient synthesis of carbohydrate analogues.
目前开发的用于合成复杂寡糖的传统方法效率不高，需要一种新的糖基化方法。在此，使用磷钨酸（PTA）作为催化剂已被证明是一种简单的碳水化合物合成方法。该方法被设计为在微波条件下进行PTA催化的硫代糖苷制备以及碳水化合物的脱乙酰化。这些更简便的操作和便捷的方案显示出广泛的底物范围。此外，这两种方法都可以发展为一锅法反应，用于高效合成碳水化合物类似物。
