Yokoyama Toshinobu, Rikimaru Toru, Kinoshita Takashi, Kamimura Tomoko, Oshita Yuichi, Aizawa Hisamichi
First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
J Infect Chemother. 2005 Apr;11(2):81-3. doi: 10.1007/s10156-004-0366-7.
We studied the clinical utility of the detection of lipoarabinomannan antibody, using MycoDot, in pleural fluid for the diagnosis of tuberculous pleurisy. Nine patients with active tuberculous pleurisy, 1 patient with chronic tuberculous empyema, and 16 patients with nontuberculous pleural effusions were studied. The results were positive in 5 patients with tuberculous pleural disease. Sensitivity was 50% (5 of 10; including the 1 patient with chronic tuberculous empyema) and specificity was 93.8% (15 of 16). Detection of lipoarabinomannan antibody using MycoDot in pleural fluid is a specific diagnostic tool for tuberculous pleurisy; furthermore, this diagnostic method is simple, rapid, and cost-effective.
我们使用MycoDot检测法研究了胸腔积液中脂阿拉伯甘露聚糖抗体检测对结核性胸膜炎诊断的临床实用性。研究对象包括9例活动性结核性胸膜炎患者、1例慢性结核性脓胸患者和16例非结核性胸腔积液患者。结果显示，10例结核性胸膜疾病患者中有5例检测结果呈阳性。敏感性为50%（10例中的5例；包括1例慢性结核性脓胸患者），特异性为93.8%（16例中的15例）。使用MycoDot检测胸腔积液中的脂阿拉伯甘露聚糖抗体是结核性胸膜炎的一种特异性诊断工具；此外，这种诊断方法简单、快速且具有成本效益。
