可溶性白细胞介素-2 受体和白细胞介素-12p40 水平是否可作为诊断结核性胸膜炎的有用标志物？

Are soluble IL-2 receptor and IL-12p40 levels useful markers for diagnosis of tuberculous pleurisy?

机构信息

Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Chest Disease.

出版信息

Infect Dis (Lond). 2015 Mar;47(3):150-5. doi: 10.3109/00365548.2014.975278. Epub 2014 Dec 31.

DOI:10.3109/00365548.2014.975278

PMID:25549699

Abstract

BACKGROUND

The differential diagnostic utilities of the levels of soluble interleukin (IL)-12p40 and the IL-2 receptor in sera and pleural effusions were evaluated in patients with exudative pleural effusions.

METHODS

We enrolled a total of 120 patients with exudative pleural effusions. The clinical, radiological, and histopathological diagnoses were tuberculous pleurisy in 52, malignant pleurisy in 39, and parapneumonic effusions in 29 patients.

RESULTS

We measured serum IL-12p40 and adenosine deaminase (ADA) levels in patients with tuberculous pleurisy and in a control group treated for pleural effusion to determine if such levels were useful in the diagnosis of pleural effusion (p < 0.005). Definite microbiological or histopathological diagnoses of tuberculous pleurisy or pleural effusion were recorded, and we found that ADA and serum soluble IL-2 receptor levels aided in diagnosis (p < 0.001). The levels of ADA and soluble IL-2 in pleural effusions afforded sensitivities and specificities of 84.62% and 82.69% and of 70.59% and 80.88%, respectively. The soluble IL-2 receptor level afforded a sensitivity and specificity of 82.69% and 52.9%. IL-12p40 levels in pleural effusions and sera afforded sensitivities and specificities of 80.77% and 80.77% and of 60.29% and 39.71%, respectively.

CONCLUSION

Soluble IL-2 receptor levels in patients with tuberculous pleurisy serve as markers of disease in non-endemic countries, similarly to ADA levels.

摘要

背景

本研究旨在评估血清和胸腔积液中可溶性白细胞介素（IL）-12p40 和 IL-2 受体水平对渗出性胸腔积液患者的鉴别诊断价值。

方法

本研究共纳入 120 例渗出性胸腔积液患者。临床、影像学和组织病理学诊断为结核性胸膜炎 52 例，恶性胸腔积液 39 例，类肺炎性胸腔积液 29 例。

结果

我们测量了结核性胸膜炎患者和胸腔积液治疗对照组的血清 IL-12p40 和腺苷脱氨酶（ADA）水平，以确定这些水平是否有助于胸腔积液的诊断（p<0.005）。明确记录了结核性胸膜炎或胸腔积液的微生物学或组织病理学诊断，我们发现 ADA 和血清可溶性 IL-2 受体水平有助于诊断（p<0.001）。ADA 和胸腔积液中可溶性 IL-2 的水平分别提供了 84.62%和 82.69%的敏感性和特异性，以及 70.59%和 80.88%的特异性。可溶性 IL-2 受体水平的敏感性和特异性分别为 82.69%和 52.9%。胸腔积液和血清中 IL-12p40 的水平分别提供了 80.77%和 80.77%的敏感性和特异性，以及 60.29%和 39.71%的特异性。