来自矮小多枝菊的细胞毒性色烯类化合物。

Cytotoxic chromenes from Myriactis humilis.

作者信息

Chen Jih-Jung, Duh Chang-Yih, Chen Ih-Sheng

机构信息

Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China.

出版信息

Planta Med. 2005 Apr;71(4):370-2. doi: 10.1055/s-2005-864107.

DOI:10.1055/s-2005-864107

PMID:15856418

Abstract

Two new chromenes, myriachromene and 2,2-dimethyl-6,7-methylenedioxy-2H-chromene, together with ten known compounds including alpha-tocopherylquinone, alpha-tocopherol acetate, diphenyl sulfone, beta-carotene, chondrillasterol, beta-sitosterol, beta-sitostenone, vanillin, and vanillic acid were isolated from the whole plant of Myriactis humilis. The structures of these new compounds were determined through spectral analyses. Among the isolates, four compounds exhibited cytotoxicity (ED50 values < 4 microg/mL) against P-388 or HT-29 cell lines in vitro.

摘要

从矮千里光全草中分离出两种新的色烯类化合物，即多歧色烯和2,2-二甲基-6,7-亚甲基二氧基-2H-色烯，以及十种已知化合物，包括α-生育酚醌、α-生育酚乙酸酯、二苯砜、β-胡萝卜素、软海绵甾醇、β-谷甾醇、β-谷甾烷酮、香草醛和香草酸。通过光谱分析确定了这些新化合物的结构。在分离出的化合物中，有四种化合物在体外对P-388或HT-29细胞系表现出细胞毒性（半数有效剂量值<4微克/毫升）。