Abubakar Mustapha N, Majinda Runner R T
Chemistry Department, University of Botswana, P/Bag 0022, Gaborone, Botswana.
Medicines (Basel). 2016 Jan 28;3(1):3. doi: 10.3390/medicines3010003.
The non-polar components of two leguminoceae species (Schumach), and (DC) were investigated. GC-MS analysis of the crude -hexane and chloroform extracts together with several chromatographic separation techniques led to the identification and characterization (using NMR) of sixteen known compounds from the heartwood and stem bark of and respectively. These constituents include, -hexadecanoic acid (palmitic acid) , oleic acid , chondrillasterol , stigmasterol , 24S 5α-stigmast-7-en-3β-ol , 9,12-octadecadienoic acid (,)-, methyl ester , 13-octadecanoic acid, methyl ester , tetradecanoic acid , hexadecanoic acid, methyl ester , octadecanoic acid , tetratriacontane , 7-dehydrodiosgenin , lupeol , stigmasta-3,5-diene-7-one , friedelan-3-one (friedelin) , and 1-octacosanol . Using agar over lay method, the preliminary antimicrobial assay for the extracts was carried out against bacterial (, , , ) and a fungus/yeast () strains. The -hexane and chloroform extracts of showed the best activity against with minimum inhibition quantity (MIQ) of 1 µg each while the remaining exhibited moderate-to-weak activity against the test microorganisms.
对两种豆科植物（舒马赫）和（德堪多）的非极性成分进行了研究。对粗己烷和氯仿提取物进行气相色谱 - 质谱分析，并结合几种色谱分离技术，分别从和的心材和茎皮中鉴定并表征（使用核磁共振）了16种已知化合物。这些成分包括十六烷酸（棕榈酸）、油酸、软骨甾醇、豆甾醇、24S 5α - 豆甾 - 7 - 烯 - 3β - 醇、9,12 - 十八碳二烯酸（，） - 甲酯、13 - 十八碳烯酸甲酯、十四烷酸、十六烷酸甲酯、十八烷酸、三十四烷、7 - 脱氢薯蓣皂苷元、羽扇豆醇、豆甾 - 3,5 - 二烯 - 7 - 酮、木栓酮（软木三萜酮）和1 - 二十八醇。采用琼脂覆盖法，对提取物针对细菌（、、、）和真菌/酵母（）菌株进行了初步抗菌试验。的己烷和氯仿提取物对表现出最佳活性，最小抑菌量（MIQ）均为1微克，而其余提取物对测试微生物表现出中度至弱的活性。
