Boston Raymond C, Moate Peter J, Stefanovski Darko, Sumner Anne E, Bergman Richard N
School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA.
Diabetes Technol Ther. 2005 Apr;7(2):298-307. doi: 10.1089/dia.2005.7.298.
The Bergman Minimal Model enables estimation of two key indices of glucose/ insulin dynamics: glucose effectiveness and insulin sensitivity.
In this paper we describe AKA-Glucose, a program that combines MINMOD Millennium (minimal model analysis software) with relational database technologies. AKA-Glucose enables the fitting of individual frequently sampled intravenous glucose tolerance test (FSIGT) data sets to the Minimal Model and the secure storage in a dedicated database (and retrieval from) of thousands of individual subjects' demographic data, their individual FSIGT data, and each subject's parameters and indices derived from minimal model analysis. AKA-Glucose also enables the population analysis of various strata or subpopulations within the database. AKA-Glucose has all of the capabilities of MINMOD Millennium, provides Minimal Model parameter estimates that are concordant with estimates from previous MINMOD software, and allows importation of data files from earlier versions of the MINMOD software.
By combining FSIGT data fitting, population analysis, and relational database technologies, AKA-Glucose is the first minimal model software designed specifically for researchers confronted with minimal model and epidemiological analysis of large numbers of either human or animal FSIGT data sets.
伯格曼最小模型能够估算葡萄糖/胰岛素动力学的两个关键指标：葡萄糖效能和胰岛素敏感性。
在本文中，我们描述了AKA - 葡萄糖程序，该程序将MINMOD Millennium（最小模型分析软件）与关系数据库技术相结合。AKA - 葡萄糖程序能够将个体频繁采样静脉葡萄糖耐量试验（FSIGT）数据集拟合到最小模型，并将数千名个体受试者的人口统计学数据、他们各自的FSIGT数据以及每个受试者从最小模型分析得出的参数和指标安全地存储在专用数据库中（并从中检索）。AKA - 葡萄糖程序还能够对数据库中的各个层次或亚群体进行总体分析。AKA - 葡萄糖程序具备MINMOD Millennium的所有功能，提供与先前MINMOD软件估算结果一致的最小模型参数估算值，并允许导入来自早期版本MINMOD软件的数据文件。
通过结合FSIGT数据拟合、总体分析和关系数据库技术，AKA - 葡萄糖程序是首个专门为面临大量人类或动物FSIGT数据集的最小模型和流行病学分析的研究人员设计的最小模型软件。
