Sledziewski Adam, Kuźmicki Mariusz, Kretowski Adam, Majkowicz-Młynarczyk Amelia, Kinalski Maciej
Zakład Rozwoju Płodu i Noworodka, Akademia Medyczna, ul M.C. Skłodowskiej 24a, 15-276 Białystok, Poland.
Med Wieku Rozwoj. 2004 Jul-Sep;8(3 Pt 2):711-8.
This paper is a review of recent reports on autoimmune aspects of gestational diabetes mellitus (GDM). In a subgroup of GDM patients distinct phenotypic and genotypic features could be distinguished. Islet autoantibodies with variable frequency are present in samples of sera taken from women with GDM. Beta-cell destruction may follow different time course patterns. For this reasons GDM patients may develop variable forms of autoimmune DM. We believe that women who experienced autoimmune GDM are at risk of type l DM and simultaneously, they are candidates for possible immunomodulatory preventive therapy in the future.
本文是一篇关于妊娠糖尿病（GDM）自身免疫方面近期报告的综述。在GDM患者的一个亚组中，可以区分出不同的表型和基因型特征。GDM女性血清样本中存在频率各异的胰岛自身抗体。β细胞破坏可能遵循不同的时间进程模式。因此，GDM患者可能会发展为不同形式的自身免疫性糖尿病。我们认为，经历过自身免疫性GDM的女性有患1型糖尿病的风险，同时，她们未来有可能成为免疫调节预防性治疗的候选对象。
