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Synthesis of aminocyclopentanols: alpha-D-galacto configured sugar mimics.

作者信息

Bøjstrup Marie, Lundt Inge

机构信息

Department of Chemistry, Technical University of Denmark, Building 201, DK-2800, Kgs. Lyngby, Denmark.

出版信息

Org Biomol Chem. 2005 May 7;3(9):1738-45. doi: 10.1039/b501824b. Epub 2005 Apr 1.

DOI:10.1039/b501824b
PMID:15858658
Abstract

Four aminocyclopentanols, as mimics of putative intermediates in the hydrolysis of alpha-d-galactosides, have been synthesized through a number of stereoselective transformations using the cis-fused cyclopentane-1,4-lactone (1R, 5S, 7R, 8R)-7,8-dihydroxy-2-oxabicyclo[3.3.0]oct-3-one as a chiral building block. The compounds were tested towards various glycosidases but showed no anomer selectivity in the inhibition of alpha- and beta-galactosidases.

摘要

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