Stanishevskaia A V, Mezentseva L N
Farmakol Toksikol. 1977 Jan-Feb;40(1):9-12.
Experiments staged on rats demonstrated that the formation of pathological states caused by stress and accompained by the development of ulcerative lesion of the gastric mucosa are associated with the degree of the catecholamines level drop in the mesencephalon and hypothalamus. The application of seduxen and also of combinations consisting of L-DOPA with seduxen, or with an L-adrenoblocking agent-pyroxan tends to reduce the frequency of developing ulcerative lesions of the stomach. The protective effect produced by the combination of L-DOPA with an L-adrenoblocking agent--pyroxan is barred by an additional administration of an beta-adrenoblocking agent--inderal.
在大鼠身上进行的实验表明，由应激引起并伴有胃黏膜溃疡性病变发展的病理状态的形成与中脑和下丘脑中儿茶酚胺水平下降的程度有关。使用速可眠以及由左旋多巴与速可眠组成的组合，或与左旋肾上腺素阻断剂吡罗昔康组成的组合，往往会降低胃溃疡性病变的发生频率。左旋多巴与左旋肾上腺素阻断剂吡罗昔康组合产生的保护作用会被额外给予β-肾上腺素阻断剂心得安所抵消。
