Papaefthimiou M, Symiakaki H, Mentzelopoulou P, Giahnaki A E, Voulgaris Z, Diakomanolis E, Kyroudes A, Karakitsos P
Department of Cytology, Alexandra Hospital, Athens, Greece.
Cytopathology. 2005 Feb;16(1):32-9. doi: 10.1111/j.1365-2303.2004.00224.x.
This study investigates the role of liquid-based cytology with ThinPrep technique, in the detection of endometrial lesions, using direct endometrial sampling from postmenopausal women with the Endogyn endometrial device.
It was performed on 491 postmenopausal women referred to our clinic for abnormal bleeding or other symptoms and/or a thickness of endometrium >5 mm on ultrasound. Endometrial sampling, dilatation and curettage (D&C) and hysterectomy were performed on all patients. For the diagnosis, the WHO classification scheme was used.
According to our findings a sensitivity of 98.08%, specificity of 100%, positive predictive value of 100%, negative predictive value of 100% and overall accuracy of 98.98% were observed in both endometrial sampling and in D&C.
Endometrial sampling is complementary to D&C for the diagnosis of endometrial lesions and it is necessary for it to be performed before D&C and/or hysterectomy.
本研究采用Endogyn子宫内膜取样器对绝经后妇女进行直接子宫内膜取样，探讨液基薄层制片技术在子宫内膜病变检测中的作用。
对491名因异常出血或其他症状和/或超声检查显示子宫内膜厚度>5mm而转诊至我院门诊的绝经后妇女进行研究。所有患者均进行了子宫内膜取样、刮宫术（D&C）和子宫切除术。诊断采用世界卫生组织分类方案。
根据我们的研究结果，子宫内膜取样和刮宫术在诊断子宫内膜病变方面的敏感性为98.08%，特异性为100%，阳性预测值为100%，阴性预测值为100%，总准确率为98.98%。
子宫内膜取样是刮宫术诊断子宫内膜病变的补充手段，在刮宫术和/或子宫切除术之前进行是必要的。
