Brown S A, Finco D R
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602.
Am J Vet Res. 1992 Apr;53(4):569-73.
Effects of a protein meal (2.7 g of casein/kg of body weight) on glomerular filtration rate (GFR) and renal plasma flow (RPF) were assessed in dogs after 15/16 nephrectomy (n = 10), and were compared with observations in dogs with intact kidneys (n = 5). Increase in GFR and RPF was observed in both groups of dogs between 1.5 and 8 hours after protein ingestion. A maximal value for GFR was observed between 4 and 5 hours after protein ingestion in dogs of both groups. Enhancement of urinary protein excretion was evident in partially nephrectomized dogs after protein ingestion (P less than 0.05), a result that was confirmed by 24-hour total urine collection from partially nephrectomized dogs fed a balanced ration. A qualitatively similar vasodilatory response was observed in partially nephrectomized dogs and in dogs with intact kidneys, and the mean maximal increase of GFR and RPF expressed as a percentage of baseline values in the latter dogs (47.0 +/- 8.1 and 43.6 +/- 10.3%, respectively) exceeded that observed in partially nephrectomized dogs (20.8 +/- 2.2 and 22.7 +/- 6.3%, respectively; P less than 0.01). The incremental response of the kidneys to protein ingestion was directly related to the degree of renal function, as reflected in the linear regression relationship between the incremental increase in GFR and the baseline value for GFR (P less than 0.01, R2 = 0.721).
在15/16肾切除术后的犬类（n = 10）中评估了蛋白质餐（2.7克酪蛋白/千克体重）对肾小球滤过率（GFR）和肾血浆流量（RPF）的影响，并与肾脏完整的犬类（n = 5）的观察结果进行了比较。在两组犬类中，蛋白质摄入后1.5至8小时观察到GFR和RPF增加。两组犬类在蛋白质摄入后4至5小时观察到GFR的最大值。蛋白质摄入后，部分肾切除的犬类尿蛋白排泄明显增加（P < 0.05），这一结果通过对喂食均衡日粮的部分肾切除犬类进行24小时总尿液收集得到证实。在部分肾切除的犬类和肾脏完整的犬类中观察到了定性相似的血管舒张反应，后者犬类中GFR和RPF的平均最大增加值相对于基线值的百分比（分别为47.0 +/- 8.1和43.6 +/- 10.3%）超过了部分肾切除犬类中观察到的增加值（分别为20.8 +/- 2.2和22.7 +/- 6.3%；P < 0.01）。肾脏对蛋白质摄入的增量反应与肾功能程度直接相关，这反映在GFR的增量增加与GFR基线值之间的线性回归关系中（P < 0.01，R2 = 0.721）。
