Brown S A
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602.
Am J Vet Res. 1994 Oct;55(10):1470-3.
Two methods for evaluating glomerular filtration rate (GFR), after single i.v. administration of inulin, were assessed in dogs after partial nephrectomy. The first method, determination of plasma clearance of inulin (PCIn), was taken as the quotient of the administered dose of inulin (1,000 mg) divided by the area under the plasma inulin concentration vs time curve. The second estimate of renal function was obtained from the plasma concentration of inulin 75 minutes after i.v. administration of 1,000 mg: C(75). The values for PCIn and C(75) were related (R2 = 0.955, P < 0.0001 and R2 = 0.867, P < 0.0001, respectively) to a previously validated method for measurement of GFR in dogs, urinary clearance of exogenous creatinine (CCr). Results of this study support use of PCIn and C(75) values to estimate GFR in dogs with reduced renal function. In particular, PCIn and C(75) were closely related to CCr in partially nephrectomized dogs with plasma creatinine concentration within the reference range for clinically normal dogs.
在部分肾切除术后的犬类中，评估了单次静脉注射菊粉后两种肾小球滤过率（GFR）评估方法。第一种方法，菊粉血浆清除率（PCIn）的测定，以菊粉给药剂量（1000mg）除以血浆菊粉浓度与时间曲线下面积的商来计算。肾功能的第二种评估方法是在静脉注射1000mg菊粉75分钟后，从菊粉的血浆浓度得出：C(75)。PCIn和C(75)的值与先前验证的犬类GFR测量方法——外源性肌酐尿清除率（CCr）相关（R2分别为0.955，P < 0.0001和R2为0.867，P < 0.0001）。本研究结果支持使用PCIn和C(75)值来估计肾功能降低的犬类的GFR。特别是，在部分肾切除且血浆肌酐浓度在临床正常犬类参考范围内的犬类中，PCIn和C(75)与CCr密切相关。
