Bowles Dianna, Isayenkova Judith, Lim Eng-Kiat, Poppenberger Brigitte
Centre for Novel Agricultural Products (CNAP), Department of Biology, University of York, York YO10 5DD, UK.
Curr Opin Plant Biol. 2005 Jun;8(3):254-63. doi: 10.1016/j.pbi.2005.03.007.
Studies of the glycosyltransferases (GTs) of small molecules have greatly increased in recent years as new approaches have been used to identify their genes and characterize their catalytic activities. These enzymes recognize diverse acceptors, including plant metabolites, phytotoxins and xenobiotics. Glycosylation alters the hydrophilicity of the acceptors, their stability and chemical properties, their subcellular localisation and often their bioactivity. Considerable progress has been made in understanding the role of GTs in the plant and the utility of GTs as biocatalysts, the latter arising from their regio- and enantioselectivity and their ability to recognize substrates that are not limited to plant metabolites.
近年来，随着用于鉴定小分子糖基转移酶（GTs）基因并表征其催化活性的新方法的出现，对小分子糖基转移酶的研究大幅增加。这些酶可识别多种受体，包括植物代谢物、植物毒素和外源化合物。糖基化会改变受体的亲水性、稳定性和化学性质、亚细胞定位，并且常常改变其生物活性。在理解GTs在植物中的作用以及GTs作为生物催化剂的效用方面已经取得了相当大的进展，后者源于它们的区域选择性和对映选择性以及识别不限于植物代谢物的底物的能力。
