D'Introno Alessia, Solfrizzi Vincenzo, Colacicco Anna M, Capurso Cristiano, Torres Francesco, Capurso Sabrina A, Capurso Antonio, Panza Francesco
Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy.
J Gerontol A Biol Sci Med Sci. 2005 Mar;60(3):280-4. doi: 10.1093/gerona/60.3.280.
The +1073 C/T polymorphism of the oxidized low-density lipoprotein receptor-1 (OLR1) gene has been reported to be associated with late-onset Alzheimer's disease, whereas for the +1071 T/A polymorphism no association was found. We genotyped 169 sporadic Alzheimer's disease patients and 264 sex- and age-matched nondemented controls from Southern Italy for OLR1 +1073 C/T and +1071 T/A polymorphisms and for apolipoprotein E and LBP-1c/CP2/LSF. We also performed haplotype analysis. For the +1073 C/T polymorphism, the C allele and the CC genotype have been associated with a higher risk for Alzheimer's disease without apolipoprotein E or CP2 interaction. The two polymorphisms were in linkage disequilibrium, with the haplotype T-C at significant increased risk of developing Alzheimer's disease in the whole sample and in elderly persons 70 years or older. In our population, the +1073 C/T OLR1 polymorphism exhibited a significant association with Alzheimer's disease, further supporting the role of OLR1 as a candidate risk gene for sporadic Alzheimer's disease.
氧化型低密度脂蛋白受体1（OLR1）基因的+1073 C/T多态性已被报道与晚发型阿尔茨海默病相关，而+1071 T/A多态性未发现有相关性。我们对来自意大利南部的169例散发性阿尔茨海默病患者以及264例性别和年龄匹配的非痴呆对照进行了OLR1 +1073 C/T和+1071 T/A多态性以及载脂蛋白E和LBP-1c/CP2/LSF的基因分型。我们还进行了单倍型分析。对于+1073 C/T多态性，C等位基因和CC基因型与无载脂蛋白E或CP2相互作用的阿尔茨海默病较高风险相关。这两种多态性处于连锁不平衡状态，单倍型T-C在整个样本以及70岁及以上老年人中患阿尔茨海默病的风险显著增加。在我们的人群中，+1073 C/T OLR1多态性与阿尔茨海默病显著相关，进一步支持了OLR1作为散发性阿尔茨海默病候选风险基因的作用。
