凝集素样氧化型低密度脂蛋白受体1（）基因多态性与汉族人群晚发型阿尔茨海默病的相关性
Association of lectin-like oxidized low density lipoprotein receptor 1 () polymorphisms with late-onset Alzheimer disease in Han Chinese.
作者信息
Wang Zuo-Teng, Zhong Xiao-Ling, Tan Meng-Shan, Wang Hui-Fu, Tan Chen-Chen, Zhang Wei, Zheng Zhan-Jie, Kong Ling-Li, Tan Lan, Sun Li
机构信息
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China.
Department of Neurology, Qingdao Central Hospital, Qingdao University, Qingdao 266042, China.
出版信息
Ann Transl Med. 2018 May;6(10):172. doi: 10.21037/atm.2018.04.31.
BACKGROUND
Lectin-like oxidized low density lipoprotein receptor 1 (OLR1) locates within the area of chromosome 12p, which has been identified as the AD-susceptible region, and plays a role in lipid metabolism. Therefore, it has been suggested to be a good candidate gene for Alzheimer's disease (AD). Several SNPs within OLR1 have been reported to have association with AD among Caucasians.
METHODS
We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese.
RESULTS
No significant association was found between the OLR1 (rs1050283, rs1050286, rs17808009) polymorphisms and LOAD, even after adjustment for gender and age and stratification for apolipoprotein E (APOE) status.
CONCLUSIONS
Our study showed that the SNPs (rs1050283, rs1050286, rs17808009) located in the 3'UTR of OLR1 may not involve in the mechanism of LOAD in Han Chinese population.
背景
凝集素样氧化低密度脂蛋白受体1（OLR1）位于12号染色体短臂区域，该区域已被确定为阿尔茨海默病易感区，且在脂质代谢中发挥作用。因此，它被认为是阿尔茨海默病（AD）的一个良好候选基因。据报道，OLR1内的几个单核苷酸多态性（SNP）在高加索人群中与AD有关联。
方法
我们选择了OLR1中的三个SNP（rs1050283、rs1050286、rs17808009）进行基因分型，以研究其与中国北方汉族984例晚发性阿尔茨海默病（LOAD）患者和1354名健康对照者发病的可能关系。
结果
即使在对性别和年龄进行校正以及按载脂蛋白E（APOE）状态分层后，也未发现OLR1（rs1050283、rs1050286、rs17808009）多态性与LOAD之间存在显著关联。
结论
我们的研究表明，位于OLR1 3'非翻译区的SNP（rs1050283、rs1050286、rs17808009）可能不参与汉族人群LOAD的发病机制。
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