Loscalzo Joseph, Voetsch Barbara, Liao Ronglih, Leopold Jane
Whitaker Cardiovascular Institute and the Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Congest Heart Fail. 2005 Mar-Apr;11(2):73-9. doi: 10.1111/j.1527-5299.2005.03854.x.
Reactive oxygen species are products of cellular metabolism and function as normal signaling molecules in the vasculature. Overproduction of reactive oxygen species that outstrips antioxidant defenses generates oxidant stress that can lead to nitric oxide depletion and endothelial cell injury, and contributes to the pathophysiology of cardiovascular disease and myocardial dysfunction. Antioxidant enzymes that are important in limiting vascular oxidant stress include superoxide dismutases, catalase, glutathione peroxidases, and glucose-6-phosphate dehydrogenase. The relevance of deficiencies in glutathione peroxidase and glucose-6-phosphate dehydrogenase on endothelial and myocardial dysfunction will be reviewed.
活性氧是细胞代谢的产物，在脉管系统中作为正常的信号分子发挥作用。活性氧的过量产生超过了抗氧化防御能力，从而产生氧化应激，这可能导致一氧化氮耗竭和内皮细胞损伤，并促成心血管疾病和心肌功能障碍的病理生理学过程。在限制血管氧化应激方面起重要作用的抗氧化酶包括超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和葡萄糖-6-磷酸脱氢酶。本文将综述谷胱甘肽过氧化物酶和葡萄糖-6-磷酸脱氢酶缺乏与内皮和心肌功能障碍的相关性。
