中度至重度一氧化碳中毒的心血管表现。
Cardiovascular manifestations of moderate to severe carbon monoxide poisoning.
作者信息
Satran Daniel, Henry Christopher R, Adkinson Cheryl, Nicholson Caren I, Bracha Yiscah, Henry Timothy D
机构信息
Division of Cardiology, University of Minnesota, Minneapolis, Minnesota, USA.
出版信息
J Am Coll Cardiol. 2005 May 3;45(9):1513-6. doi: 10.1016/j.jacc.2005.01.044.
OBJECTIVES
We describe the cardiovascular manifestations of carbon monoxide (CO) poisoning.
BACKGROUND
Carbon monoxide poisoning is a common cause of toxicologic morbidity and mortality. Although the neurologic sequelae of CO poisoning have been well described, the cardiovascular consequences are limited to isolated case reports.
METHODS
We reviewed the cardiovascular manifestations of 230 consecutive patients treated for moderate to severe CO poisoning in the hyperbaric oxygen chamber at Hennepin County Medical Center (HCMC), a regional center for treatment of CO poisoning.
RESULTS
The mean age was 47.2 years with 72% men. Ischemic electrocardiogram (ECG) changes were present in 30% of patients, whereas only 16% had a normal ECG. Cardiac biomarkers (creatine kinase-MB fraction or troponin I) were elevated in 35% of patients. In-hospital mortality was 5%.
CONCLUSIONS
Cardiovascular sequelae of CO poisoning are frequent, with myocardial injury assessed by biomarkers or ECG in 37% of patients. Patients admitted to the hospital with CO poisoning should have a baseline ECG and serial cardiac biomarkers.
目的
我们描述一氧化碳（CO）中毒的心血管表现。
背景
一氧化碳中毒是导致毒理学发病和死亡的常见原因。尽管一氧化碳中毒的神经后遗症已有详尽描述，但心血管方面的后果仅局限于个别病例报告。
方法
我们回顾了在亨内平县医疗中心（HCMC）高压氧舱接受治疗的230例中重度一氧化碳中毒连续病例的心血管表现，HCMC是一氧化碳中毒治疗的区域中心。
结果
平均年龄为47.2岁，男性占72%。30%的患者出现缺血性心电图（ECG）改变，而仅有16%的患者心电图正常。35%的患者心脏生物标志物（肌酸激酶-MB同工酶或肌钙蛋白I）升高。住院死亡率为5%。
结论
一氧化碳中毒的心血管后遗症很常见，37%的患者通过生物标志物或心电图评估存在心肌损伤。因一氧化碳中毒入院的患者应进行基线心电图检查和系列心脏生物标志物检测。
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