Sanz Clara, Moreno Fernando, Armas Alvaro, Casado Antonio, Castillo M C
Gynecology Department, Hospital La Paz, Madrid, Spain.
Gynecol Oncol. 2005 May;97(2):677-80. doi: 10.1016/j.ygyno.2004.12.061.
Angiosarcomas account for less than 2% of all sarcomas. However, they represent 15% of radiotherapy-induced sarcomas, usually associated to the treatment for breast cancer, cervical cancer, and lymphomas.
We report the case of a 56-year-old patient who developed a soft tissue angiosarcoma in the right groin 25 years after receiving radiotherapy for vulvar cancer. To our knowledge, this is the second case reported of a soft tissue angiosarcoma after radiotherapy for a vulvar cancer.
Postradiation sarcoma must be considered in patients with a history of a previous tumor when a soft tissue mass is seen in the previously irradiated field, especially if the latent period is more than 3 or 5 years. The correct histologic interpretation of such lesions is important because it may result in early identification of the secondary malignancy and may contribute to better management and improved prognosis.
血管肉瘤占所有肉瘤的比例不到2%。然而,它们占放疗诱发肉瘤的15%,通常与乳腺癌、宫颈癌和淋巴瘤的治疗相关。
我们报告一例56岁患者,其在外阴癌放疗25年后,右侧腹股沟出现软组织血管肉瘤。据我们所知,这是第二例报道的外阴癌放疗后发生的软组织血管肉瘤。
既往有肿瘤病史的患者,若在先前放疗区域出现软组织肿块,尤其是潜伏期超过3年或5年时,必须考虑放疗后肉瘤。对此类病变进行正确的组织学解读很重要,因为这可能有助于早期识别继发性恶性肿瘤,并有助于更好地管理和改善预后。