Kim M K, Huh S J, Kim D Y, Yang J H, Han J, Ahn Y C, Lim D H
Department of Radiation Oncology, Samsung Medical Center, Seoul, Korea.
Radiat Med. 1998 Jan-Feb;16(1):55-60.
Angiosarcoma is a rare malignant tumor that accounts for 1% to 2% of all soft tissue sarcomas. This paper reports a case of radiation-associated angiosarcoma with a literature review of 66 cases. Twenty-nine years after transabdominal hysterectomy and adjuvant radiation therapy for uterine cervix cancer, cutaneous angiosarcoma developed in the abdominal wall of a 63-year-old woman. She underwent wide excision of the abdominal wall mass, radiation therapy, and chemotherapy, and has been alive and well without any evidence of metastasis for 23 months since the initial diagnosis of angiosarcoma. After an intensive literature review, we found 66 cases of radiation-associated angiosarcoma. The most common primary disease was breast cancer (44%), with gynecologic cancer (21%) next. Eighty-five percent of radiation-associated angiosarcomas developed in the cutaneous area. The median age at diagnosis was 65 years, and the median latency period from irradiation to diagnosis was 96 months. The median survival period of 48 patients whose survival lengths could be reviewed was 12 months.
血管肉瘤是一种罕见的恶性肿瘤，占所有软组织肉瘤的1%至2%。本文报告一例与放疗相关的血管肉瘤病例，并对66例病例进行文献回顾。在因子宫颈癌接受经腹子宫切除及辅助放疗29年后，一名63岁女性的腹壁出现皮肤血管肉瘤。她接受了腹壁肿块广泛切除、放疗及化疗，自血管肉瘤初诊以来已存活23个月，无任何转移迹象。经过深入的文献回顾，我们发现了66例与放疗相关的血管肉瘤病例。最常见的原发疾病是乳腺癌（44%），其次是妇科癌症（21%）。85%的与放疗相关的血管肉瘤发生在皮肤区域。诊断时的中位年龄为65岁，从放疗到诊断的中位潜伏期为96个月。48例可回顾生存时长的患者的中位生存期为12个月。
