巴西和日本近平滑念珠菌临床分离株内部转录间隔区（ITS）及5.8S rRNA基因的遗传多样性
Genetic diversity of the internal transcribed spacers (ITS) and 5.8S rRNA genes among the clinical isolates of Candida parapsilosis in Brazil and Japan.
作者信息
Iida Soji, Imai Tamae, Oguri Toyoko, Okuzumi Katsuko, Yamanaka Ademar, Moretti-Branchini Maria Luiza, Nishimura Kazuko, Mikami Yuzuru
机构信息
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan.
出版信息
Nihon Ishinkin Gakkai Zasshi. 2005;46(2):133-7. doi: 10.3314/jjmm.46.133.
The internal transcribed spacer (ITS) region including 5.8S rDNA sequences of 58 isolates of Candida parapsilosis in Brazil and Japan was analyzed. Although most of the C. parapsilosis strains tested were confirmed to belong to three already reported genetically distinct groups (I, II and III) based on their ITS region sequences, 5 strains of the Brazilian isolates showed different sequences from those heretofore reported and suggested a presence of new genotype. For these strains of C. parapsilosis, we proposed a new genetic group (IV). The sequence similarities of this new group of IV to I, II and III were 87.4%, 94.7% and 87.3% in the ITS1 region, respectively. Genetic diversity in ITS regions of the remaining C. parapsilosis strains in Brazil and Japan was also discussed.
对巴西和日本的58株近平滑念珠菌的内部转录间隔区（ITS），包括5.8S rDNA序列进行了分析。尽管根据ITS区域序列，测试的大多数近平滑念珠菌菌株被证实属于三个已报道的遗传上不同的组（I、II和III），但5株巴西分离株显示出与迄今报道的序列不同，并提示存在新的基因型。对于这些近平滑念珠菌菌株，我们提出了一个新的遗传组（IV）。这个新的IV组在ITS1区域与I、II和III组的序列相似性分别为87.4%、94.7%和87.3%。还讨论了巴西和日本其余近平滑念珠菌菌株ITS区域的遗传多样性。
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