肝脏胰岛素受体在葡萄糖生成调节中的作用。
The role of hepatic insulin receptors in the regulation of glucose production.
作者信息
Cherrington Alan D
机构信息
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
出版信息
J Clin Invest. 2005 May;115(5):1136-9. doi: 10.1172/JCI25152.
Abstract
The inability of insulin to suppress hepatic glucose production (HGP) is a key defect found in type 2 diabetes. Insulin inhibits HGP through both direct and indirect means, the latter of which include inhibition of glucagon secretion, reduction in plasma nonesterified fatty acid level, decrease in the load of gluconeogenic substrates reaching the liver, and change in neural signaling to the liver. Two studies in this issue of the JCI demonstrate that selective changes in the expression of insulin receptors in mouse liver do not have a detectable effect on the ability of insulin to inhibit HGP (see the related articles beginning on pages 1306 and 1314). These provocative data suggest that the indirect effects of insulin on the liver are the primary determinant of HGP in mice.
摘要
胰岛素无法抑制肝糖生成（HGP）是2型糖尿病中发现的一个关键缺陷。胰岛素通过直接和间接两种方式抑制肝糖生成，后者包括抑制胰高血糖素分泌、降低血浆非酯化脂肪酸水平、减少到达肝脏的糖异生底物负荷以及改变向肝脏的神经信号传导。本期《临床研究杂志》上的两项研究表明，小鼠肝脏中胰岛素受体表达的选择性变化对胰岛素抑制肝糖生成的能力没有可检测到的影响（见第1306页和1314页开始的相关文章）。这些引人深思的数据表明，胰岛素对肝脏的间接作用是小鼠肝糖生成的主要决定因素。
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