Eriksson C J Peter, Kaprio Jaakko, Pulkkinen Lea, Rose Richard J
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland.
Behav Genet. 2005 May;35(3):359-68. doi: 10.1007/s10519-005-3228-x.
We examined associations of testosterone (T) and alcohol use in adolescent twin brothers, conducting both between- and within-family analyses. The twins completed semi-structured interviews, provided two saliva samples to assay T, and reported their drinking patterns and pubertal development. We adjusted T levels for diurnal/seasonal effects and association with pubertal maturation. In analyses of twins as individuals, higher T levels characterized boys reporting ever drinking, more frequent intoxication, high density drinking, more alcohol symptoms, and diagnosed alcohol dependency on interview. Adjusting for pubertal development, only associations with symptom count and diagnosis remained significant. The association with frequent intoxication replicated among drinking-discordant twin brothers, effectively ruling out between-family confounds, but that association was not significant after adjustment for pubertal development. The phenotypic correlation between T and pubertal maturation is largely genetic, inviting study of the magnitude and meaning of linkages between testosterone and symptoms of alcoholism on follow-up in early adulthood.
我们对青春期双胞胎兄弟的睾酮（T）与饮酒情况之间的关联进行了研究，同时进行了家庭间和家庭内分析。双胞胎完成了半结构化访谈，提供了两份唾液样本以检测T，并报告了他们的饮酒模式和青春期发育情况。我们对T水平进行了昼夜/季节效应以及与青春期成熟度关联的调整。在将双胞胎作为个体进行分析时，报告曾饮酒、更频繁醉酒、高密度饮酒、更多酒精相关症状以及在访谈中被诊断为酒精依赖的男孩，其T水平较高。在对青春期发育进行调整后，仅与症状数量和诊断的关联仍具有显著性。在饮酒情况不一致的双胞胎兄弟中，与频繁醉酒的关联得到了重复，有效排除了家庭间混杂因素，但在对青春期发育进行调整后，该关联并不显著。T与青春期成熟之间的表型相关性在很大程度上是由基因决定的，这促使我们在成年早期进行随访研究，以探究睾酮与酒精中毒症状之间联系的程度和意义。
