Fredlund H, Selldén H, Danielsson D, Olcén P
Department of Clinical Microbiology and Immunology, Orebro Medical Center Hospital, Sweden.
APMIS. 1992 May;100(5):449-54. doi: 10.1111/j.1699-0463.1992.tb00896.x.
In an earlier study, with the use of chemiluminescence (CL) and phagocytic killing, we could show that in the presence of serum from healthy adults polymorphonuclear leukocytes (PMNL) efficiently handle nonpathogenic Neisseria meningitidis strains, in sharp contrast to those associated with clinical disease. The major part of this difference was dependent on serum factors. In the present study 84 serum samples from children 1-3, 4-6, 7-9, and 10-14 years old were studied by the CL technique according to their ability to opsonize meningococci. There was a highly significant difference (p less than 0.001) in all four age groups when the CL indexes obtained with the pathogenic meningococci of the serogroups A, B and C were compared with those of the nonpathogenic menigococci: serogroup 29E and nongroupable meningococci. These findings imply that the ability to opsonize so-called nonpathogenic meningococci is developed early in life and may explain why they are only occasionally able to cause disease.
在一项早期研究中，通过化学发光（CL）和吞噬杀伤作用，我们发现，在健康成年人血清存在的情况下，多形核白细胞（PMNL）能够有效处理非致病性脑膜炎奈瑟菌菌株，这与那些与临床疾病相关的菌株形成鲜明对比。这种差异的主要部分取决于血清因子。在本研究中，采用CL技术，根据血清对脑膜炎球菌的调理作用能力，对1至3岁、4至6岁、7至9岁和10至14岁儿童的84份血清样本进行了研究。当将A、B和C血清群致病性脑膜炎球菌与非致病性脑膜炎球菌（29E血清群和不可分组脑膜炎球菌）的CL指数进行比较时，所有四个年龄组均存在极显著差异（p小于0.001）。这些发现表明，调理所谓非致病性脑膜炎球菌的能力在生命早期就已形成，这可能解释了为什么它们只是偶尔能够引起疾病。
