Weil Clifford
Department of Agronomy, Purdue University, West Lafayette, IN 47907-1150, USA.
Trends Biotechnol. 2005 May;23(5):220-2. doi: 10.1016/j.tibtech.2005.03.001.
Finding a way to identify point mutants for a genome in which there are six copies of every gene seems a daunting task, however this has recently been reported. In this research, the redundancy in the wheat genome proved a help instead of a hindrance and the results suggest a promising approach in functional genomics of polyploid crop species. It is now feasible to generate point mutations in all the homologs for a particular gene directly in a polypoid commercial crop variety and then combine them, thus avoiding undesirable, linked traits that often complicate introgressing traits into crops from wild relatives.
对于一个每个基因都有六个拷贝的基因组而言，找到一种识别点突变体的方法似乎是一项艰巨的任务，不过最近已有相关报道。在这项研究中，小麦基因组中的冗余性被证明是一种助力而非阻碍，研究结果表明了在多倍体作物物种功能基因组学方面的一种很有前景的方法。现在，直接在一个多倍体商业作物品种中针对特定基因的所有同源基因产生点突变，然后将它们组合起来是可行的，这样就能避免那些常常会使将性状从野生亲缘种导入作物的过程变得复杂的不良连锁性状。
