Vastel Laurent, Lambert Patrick, De Pinieux Gonzague, Charrois Olivier, Kerboull Marcel, Courpied Jean-Pierre
Cochin University Hospital, Paris, France.
J Bone Joint Surg Am. 2005 May;87(5):1019-24. doi: 10.2106/JBJS.C.01297.
Pigmented villonodular synovitis of the hip is a rare disease. Synovectomy is generally accepted as the only surgical treatment for the disorder, but there have been few studies with a sufficient sample size and duration of follow-up to allow the evaluation of long-term outcomes. The aim of this study was to determine the long-term outcome of the treatment in sixteen patients.
Sixteen patients (nine men and seven women), with a mean age of 35.5 years at the time of surgery, were treated between 1970 and 1996. Complete synovectomy was performed in all patients; in addition, three had a cup arthroplasty, four had a total hip arthroplasty, and one had a monopolar arthroplasty. Clinical and radiographic outcomes were evaluated retrospectively at a mean of 16.7 years postoperatively. Only one patient was followed for less than eight years.
Nine patients needed repeat surgery, but only one had recurrent synovitis, as detected with pathological examination fourteen years after treatment with synovectomy and cup arthroplasty. Secondary osteoarthritis developed in all eight patients who had been treated with synovectomy alone, and four of them required a total hip arthroplasty within the follow-up period.
These results support earlier data indicating that osteoarthritis consistently develops in patients with pigmented villonodular synovitis of the hip. Complete synovectomy seems to be effective in preventing recurrence of the synovitis, but it does not appear to prevent the development of secondary osteoarthritis.
髋关节色素沉着绒毛结节性滑膜炎是一种罕见疾病。滑膜切除术通常被认为是该疾病唯一的手术治疗方法,但很少有研究具备足够的样本量和随访时间来评估长期疗效。本研究的目的是确定16例患者治疗的长期疗效。
16例患者(9例男性,7例女性),手术时平均年龄35.5岁,于1970年至1996年接受治疗。所有患者均进行了彻底的滑膜切除术;此外,3例行髋臼成形术,4例行全髋关节置换术,1例行单极人工关节置换术。术后平均16.7年对临床和影像学结果进行回顾性评估。只有1例患者随访时间少于8年。
9例患者需要再次手术,但只有1例出现复发性滑膜炎,这是在滑膜切除术和髋臼成形术治疗14年后经病理检查发现的。仅接受滑膜切除术治疗的8例患者均出现继发性骨关节炎,其中4例在随访期间需要行全髋关节置换术。
这些结果支持了早期数据,表明髋关节色素沉着绒毛结节性滑膜炎患者会持续发展为骨关节炎。彻底的滑膜切除术似乎能有效预防滑膜炎复发,但似乎无法预防继发性骨关节炎的发展。