Franco Oscar H, Burger Huibert, Lebrun Corinne E I, Peeters Petra H M, Lamberts Steven W J, Grobbee Diederick E, Van Der Schouw Yvonne T
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands.
J Nutr. 2005 May;135(5):1190-5. doi: 10.1093/jn/135.5.1190.
Data on the relation between phytoestrogens and cognitive function are still sparse. The purpose of this study was to examine the relation between the dietary intake of phytoestrogens and cognitive function in healthy postmenopausal women consuming a Western diet. We conducted a community-based survey among 394 postmenopausal women. Isoflavone and lignan intake was calculated from a validated FFQ. Cognitive function was evaluated using the Mini-Mental State Examination (MMSE). Data were analyzed using logistic regression with intact cognitive function defined as a score >/= 26 as the outcome variable. After adjustment for confounders, increasing dietary lignans intake was associated with better performance on the MMSE [OR and (95%CI): 1.49 (0.94-2.38)]. Results were most pronounced in women who were 20-30 y postmenopausal [2.02 (1.11-3.71)]. Isoflavone intake was not related to cognitive function. From our results we conclude that higher dietary intake of lignans is associated with better cognitive function in postmenopausal women.
关于植物雌激素与认知功能之间关系的数据仍然稀少。本研究的目的是调查食用西方饮食的健康绝经后女性中植物雌激素的膳食摄入量与认知功能之间的关系。我们对394名绝经后女性进行了一项基于社区的调查。异黄酮和木脂素的摄入量通过经过验证的食物频率问卷计算得出。使用简易精神状态检查表（MMSE）评估认知功能。以完整认知功能（定义为得分≥26）作为结果变量，采用逻辑回归分析数据。在对混杂因素进行调整后，膳食木脂素摄入量的增加与MMSE表现更好相关[比值比及（95%可信区间）：1.49（0.94 - 2.38）]。结果在绝经后20 - 30年的女性中最为显著[2.02（1.11 - 3.71）]。异黄酮摄入量与认知功能无关。根据我们的结果，我们得出结论，绝经后女性膳食中木脂素摄入量较高与较好的认知功能相关。
