Kreijkamp-Kaspers Sanne, Kok Linda, Grobbee Diederick E, de Haan Edward H F, Aleman André, van der Schouw Yvonne T
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.
J Gerontol A Biol Sci Med Sci. 2007 May;62(5):556-62. doi: 10.1093/gerona/62.5.556.
Aging is associated with a decline in cognitive function; we explored the possible influence of dietary phytoestrogens on this decline.
We conducted a cross-sectional study in 301 Dutch women aged 60-75 years. Dietary isoflavone and lignan intake was assessed with a food-frequency questionnaire covering habitual diet in the year preceding enrolment. The endpoints were cognitive function measured in three domains: memory, processing capacity and speed, and executive function. Data were analyzed using linear regression models, after adjusting for confounders.
No association between dietary isoflavone intake and cognitive function was found. High lignan intake was associated with a better performance in processing capacity and speed, and in executive function (p for trend over quartiles =.01 and.02, respectively).
This finding calls for further research to elucidate the relatively underexplored role of lignans within the range of phytoestrogens.
衰老与认知功能下降有关；我们探讨了膳食植物雌激素对这种下降的可能影响。
我们对301名年龄在60 - 75岁的荷兰女性进行了一项横断面研究。使用涵盖入组前一年习惯饮食的食物频率问卷评估膳食异黄酮和木脂素的摄入量。终点是在三个领域测量的认知功能：记忆、处理能力和速度以及执行功能。在对混杂因素进行调整后，使用线性回归模型分析数据。
未发现膳食异黄酮摄入量与认知功能之间存在关联。高木脂素摄入量与处理能力和速度以及执行功能方面的更好表现相关（四分位数趋势的p值分别为0.01和0.02）。
这一发现需要进一步研究，以阐明木脂素在植物雌激素范围内相对未被充分探索的作用。
