Zarrindast Mohammad R, Khalilzadeh Azita, Rezayat S Mehdi, Sahebgharani Mousa, Djahanguiri Bijan
Department of Pharmacology, School of Medicine, Teheran University of Medical Sciences, Teheran, Iran.
Pharmacology. 2005 May;74(2):106-12. doi: 10.1159/000085590. Epub 2005 May 3.
The effects of histaminergic drugs on morphine state-dependent memory of a passive avoidance task were examined in mice. Pre-training administration of morphine (5 mg/kg) led to state-dependent learning with impaired memory recall on the test day which was reversed by pre-test administration of the same dose of the opioid. The pre-test intracerebroventricular (i.c.v.) administration of the H(1) blocker (pyrilamine) prevented the restoration of memory by morphine. The H(2) blocker (ranitidine) was ineffective in this regard and the H(3) blocker (clobenpropit) potentiated the effect of morphine on memory recall. The pre-test i.c.v. administration of histamine alone (5, 10, and 20 microg/mouse) not only mimicked the effect of pre-test morphine treatment, but also increased this action of the opioid. The effect of histamine on memory recall was not changed by the pre-test administration of mu-opioid receptor antagonist, naloxone. In conclusion, the improvement of memory recall by morphine treatment, on the test day, seems to be, at least in part, through the release of histamine followed by the stimulation of H(1) receptors. Histamine by itself, when administered on the test day, mimicked morphine-induced memory improvement by a mechanism independent of the mu-opioid receptors.
在小鼠中研究了组胺能药物对被动回避任务的吗啡状态依赖性记忆的影响。吗啡（5毫克/千克）预训练给药导致状态依赖性学习，在测试日记忆回忆受损，而相同剂量的阿片类药物预测试给药可逆转这种情况。H(1)受体阻滞剂（吡苄明）预测试脑室内（i.c.v.）给药可阻止吗啡恢复记忆。H(2)受体阻滞剂（雷尼替丁）在这方面无效，而H(3)受体阻滞剂（氯苯丙哌嗪）增强了吗啡对记忆回忆的作用。仅在预测试时i.c.v.给予组胺（5、10和20微克/小鼠）不仅模拟了预测试吗啡治疗的效果，还增强了阿片类药物的这种作用。组胺对记忆回忆的作用不会因预测试给予μ-阿片受体拮抗剂纳洛酮而改变。总之，吗啡治疗在测试日对记忆回忆的改善似乎至少部分是通过组胺释放继而刺激H(1)受体实现的。组胺在测试日单独给药时，通过一种独立于μ-阿片受体的机制模拟了吗啡诱导的记忆改善。
